Blockchain is a revolutionary computer bottom technology. As a brand-new information storage, dissemination and management mechanism, it realizes reliable transfer of data and value and is a master of cryptography, distributed systems and game theory. At present, blockchain technology is in the process of accelerating evolution and development, from its initial application in digital cash to its present extension to digital finance, Internet of Things, intelligent manufacturing, supply chain management, digital asset transactions and other fields. In addition, the vigorous development of digital technology makes massive data generate every day, which also brings challenges to information security and privacy protection. ICBCTIS 2025 aims to gather researchers and industry practitioners in blockchain and information security-related fields, focusing on the cutting-edge technologies of blockchain in distributed systems, cryptography, data management and analysis, economic models, regulatory technologies and other fields, as well as new applications of blockchain systems in different industries.